Author Archives: Ken Ekechukwu

Sonography of the arteries of the lower limbs. Ken U. Ekechukwu, MD, MPH, FACP.

What is lower limb?
Humans are bipeds, animals with 2 legs. We also have 2 arms. In medical terminology each of the legs and arms is called a limb or an extremity, the arms being upper limbs (or upper extremities) and the legs, the lower limbs (or lower extremities).

What are arteries of the lower limbs?
An artery is a vessel that carries fresh blood from the heart to other parts of the body, while a vein carries oxygenated blood to the heart to be pumped to the lungs for oxygenation. The aorta is the large artery that carries blood from the heart and distributes it to the rest of the body. The portion of the aorta in the chest is called the thoracic aorta and the portion in the abdomen or belly, the abdominal aorta. In the chest and the abdomen the aorta lies in the back, next to the spinal column. It is the largest artery in the body, measuring about 3 cm in the chest and 2.5 cm in the abdomen. These measurements vary for men and women.   Somewhere about the level of the belly button the abdominal aorta splits into two to become the common iliac arteries. These arteries carry on past the waist line and enter into the lower extremities, becoming known by different names as they pass through and branch in the thighs, the knees, the legs proper, until they arrive feet, much like some long major roads are known by different names as they pass through different cities and towns. (Now you see why city roads are sometimes called arterials.) The arteries that pass through the lower extremities are called lower limb (extremity) arteries.

What is Doppler ultrasound examination?
If you yell loud enough in an empty hall way or warehouse you will notice that the echo of your voice comes back to you. This is because the walls around you reflect the sound waves back to you.    Did you know that when sound waves travel through media of different compositions like water, air, and solid they change their directions and are reflected, scattered or absorbed,  while some loose energy?

Did you also know that there are sound waves, called ultrasound (or ultrasonic) waves, whose frequencies of oscillation (number of back-and-forth movements in a given second) put them beyond perception by the human ears though they behave in much the same way as the waves we hear? The US Navy used knowledge of these principles of sound behavior to detect objects in the bowels of the sea in the Second World War. Today we use them in examining practically all parts of the body in what is called ultrasonography (ultra– is Latin prefix that denotes “beyond”, sonus is Latin for sound, -graphia is Greek suffix derived from graphein, which means to write). In a sense we write or express on paper for the eyes to see the way these ultrasonic waves are transmitted through and reflected from the body tissues.

A small hand-held instrument, generally rectangular in configuration and called an ultrasound transducer, contains a small strip of crystal in one of its shorter ends, which converts electrical energy into short bursts of ultrasonic waves of predetermined frequency. It then “listens” briefly for echoes of these waves coming from tissues of the body and repeats the cycle. The transducer each time reconverts the reflected waves into electrical energy that a computer in the ultrasound machine then expresses on a screen as pixels of black, white, and varying degrees of gray: black represents complete absence of any returned waves as happens when all the dispatched waves pass through a simple cyst; white represents intense or complete reflection of the waves back to the transducer as happens when the waves hit an impenetrable solid structure like bone or calcium; and the varying levels of gray express the different intensities of the reflected waves as happens when the waves strike soft parts of the body.

As you know, the body is made of tissues of varying compositions that lie at varying depths from the skin. Using mathematical equations which incorporate the speed of the waves through body tissues, the time lapse between the sending and receiving of the waves, and the difference in intensity between the sent and received waves, the computer graphically expresses on a screen an “image” of the examined part of the body for the eyes to see. This is gray-scale sonography.

Have you noticed that when an ambulance approaches you blaring its siren that the pitch of the siren rises in intensity as the ambulance draws nearer and gradually fades as it recedes from you? Well, Christian Johann Doppler, an Austrian physicist and mathematician, constructed a mathematical equation that describes this experience and we use this equation in building ultrasound concepts specifically designed to examine arteries and veins. This method of ultrasound examination of vessels is called Doppler ultrasonography in honor of the Austrian. Qualifications like color Doppler ultrasonography and pulsed Doppler ultrasonography are color-coded and graphic expressions of this mathematical equation, respectively. 

What happens is that we send ultrasonic waves of predetermined frequency from a transducer to examine moving red blood cells in the arteries and veins. A change occurs in the frequencies of the reflected waves governed, in part, by the angle at which the sound hits the cells and their directions of movement. A computer uses these differences in frequencies to describe the speed and direction of the cells traveling through the arteries and veins. Narrowing, occlusion, and abnormal dilation of arteries and veins affect the speed and direction of the red blood cells.

Thus, arterial Doppler ultrasound of the lower extremities is a special ultrasound examination of the structure of the arteries of the lower limbs and the way the red blood cells flow through them.

Why do I need arterial Doppler ultrasound examination of my lower limbs?
Normally, the pressure of blood flow through the mid arm of an upper extremity equals the amount flowing across the ankle into the foot, all things being equal.

Diseases like diabetes mellitus, hypertension, and high cholesterol, especially when poorly controlled, and cigarette smoking damage arterial walls. In time, the damage translates from bulges in the walls of the arteries to complete occlusion, causing diminished or complete lack of flow, respectively. Normally, you don’t notice these events until the disease obstructs more than 50% of the diameter of the artery. This is when you may begin to feel cramps in your buttocks, thighs, or legs, initially when you are walking and, later, at rest. Some men may develop erectile dysfunction. As time goes on, a certain percentage of people with this problem will begin to notice changes in the color of the skin of their legs and feet and some may experience odd sensations too. Ultimately, if nothing is done, the skin may break down, wounds may not heal or delay doing so, and in extreme cases, gangrene sets in and the patient looses a limb. This spectrum of diseases is known as peripheral arterial disease to distinguish it from similar conditions that occur in arteries that feed the brain (carotid artery stenosis) and the heart (coronary artery disease). It includes obstructive disease of the arteries to the kidneys and intestines.

Arterial Doppler ultrasound allows us to screen for peripheral arterial disease without invading the body with needles, wires, and catheters and provides us with template information on which to build treatment strategies when the disease is present.

What should I expect at arterial Doppler ultrasound of my lower limbs?
Your only preparation is to show up for the study. It is simple, painless, quick, and useful. A gel will be placed on the skin over the artery in question to “bond” the transducer (the little instrument the technologist will place on your body) to your skin so that the sound waves can pass well across the skin and the transducer. Most patients go home soon after the examination unless its findings suggest otherwise, in which case some one will notify you immediately.

Sonography of the carotid arteries. Ken U. Ekechukwu, MD, MPH, FACP.

What is Carotid artery?
An artery is a vessel that carries fresh blood from the heart to another part of the body, while a vein returns used blood to the heart to be pumped to the lungs for oxygenation. (The exceptions to this rule are the pulmonary artery, which carries impure blood from the heart to the lungs and the pulmonary veins, which return oxygenated blood from the lungs to the heart.)

Two arteries, one on each side of the neck, carry blood from the thoracic aorta to the head and neck region of the body. They are called the carotid arteries (from the Greek word, karotis, which means deep sleep). Somewhere around the angle of the jaw bone these arteries split into two: one branch, the smaller, feeds all the tissues of the face and most of the tissues of the neck, while the second and larger branch, entering through the base of the skull, participates in supplying blood to the brain. This portion of the brain’s blood supply is called the anterior circulation. Another pair of arteries, much smaller than the carotid arteries, arises from the arteries that carry blood into the upper extremities and supply the posterior circulation of the brain. These are called the vertebral arteries because they travel through holes in the wings of the vertebral bodies that make the spinal column of the neck.

What is Doppler ultrasound examination?
If you yell loud enough in an empty hall way or warehouse you will notice that after a pause the echo of your voice comes back to you. This is because the walls surrounding you reflect the sound waves back to you.  Did you know that when sound waves travel through media of different compositions like water, air, and solid they change their directions and are reflected, scattered or absorbed, while loose some energy?

Did you also know that there are sound waves called ultrasound (or ultrasonic) waves, whose frequencies of oscillation (number of back-and-forth movements in a given second) put them beyond perception by the human ears, though they behave in much the same way as the waves we hear? The Navy used knowledge of these principles of sound behavior in the Second World War to detect objects in the bowels of the sea. Today, we use them in examining practically all parts of the body in what is called ultrasonography (ultra- is Latin prefix that denotes “beyond”, sonus is Latin for sound, -graphia is Greek suffix derived from graphein, which means to write). In a sense we write or express on paper for the eyes to see the way these ultrasonic waves are transmitted through and reflected from the body tissues.

A small hand-held instrument, generally rectangular in configuration and called an ultrasound transducer, contains a small strip of crystal in one of its shorter ends which converts electrical energy into short bursts of ultrasonic waves of predetermined frequency. It then “listens” briefly for reflected echoes of these waves coming from tissues of the body and repeats the cycle. The transducer each time reconverts the reflected waves into electrical energy that a computer in the ultrasound machine then expresses on a screen as pixels of black, white, and varying degrees of gray: black representing complete absence of any returned waves as happens when all the dispatched waves pass through a simple cyst; white representing intense or complete reflection of the waves back to the transducer as happens when the waves hit an impenetrable solid structure like bone or calcium; and the varying levels of gray express the different intensities of the reflected waves as happens when the waves strike soft parts of the body.

Now, as you can know, the body is made of tissues of varying compositions which lie at varying depths from the transducer. Using mathematical equations which incorporate the speed of the waves through body tissues, the time lapse between the sending and receiving of the waves, and the difference in intensity between the sent and received waves, the computer graphically expresses on a screen an “image” of the examined part of the body for the eyes to see. This is gray-scale sonography.

Have you noticed that when an ambulance approaches you blaring its siren that the pitch of the siren rises in intensity as the ambulance approaches and gradually fades as it recedes from you? Well, Christian Johann Doppler, an Austrian physicist and mathematician, constructed a mathematical equation that describes this experience and we use this equation in building ultrasound concepts specifically designed to examine arteries and veins. This method of ultrasound examination of vessels is called Doppler ultrasonography in honor of the Austrian. Qualifications like color Doppler ultrasonography and pulsed Doppler ultrasonography are color-coded and graphic expressions of this mathematical equation, respectively. 

What happens is that we send ultrasonic waves of predetermined frequency from a transducer to examine moving red blood cells in the arteries and veins. A change occurs in the frequencies of the reflected waves governed, in part, by the angle at which the sound hits the blood cells and their directions of movement. A computer uses these differences in frequencies to describe the speed and direction of the blood cells through the vessels. Narrowing, occlusion, and abnormal dilation of arteries and veins affect the speed and direction of the red blood cells.

Why do I need carotid ultrasound examination?
Stroke is the third leading cause of death and a principal maimer in the western hemisphere as well as the rest of the world. One of its causes is disease of the carotid and vertebral arteries (see above). So we use this examination to screen or search for causes (s) of a stroke. Besides neurological deficits that constitute a stroke, other warning symptoms and signs of diseased carotid and vertebral arteries are dizziness, syncope, and near-syncope. By performing ultrasound examination of the carotid and vertebral arteries one can diagnose or suggest these problems. There is a good chance that one of such considerations must have prompted your doctor to recommend this examination for you.

What should I expect during carotid ultrasound examination?
Your only preparation for the examination is to show up for it. It is simple, painless, and quick. Gel will be placed on the skin over the artery in question to “bond” the transducer (the little instrument the technologist will place on your body) to your skin so that the sound waves can pass well across the skin into and from the transducer.  Most patients go home soon after the examination unless its findings rule otherwise, in which case some one will notify you immediately.

Decompressing and stenting obstructed biliary ducts. Ken U. Ekechukwu, MD, MPH, FACP.

What is biliary decompression and stenting?
The word biliary derives from the small tubes or canals in the liver called bile ducts that drain bile which the liver makes into the gallbladder and the intestine. These tubes branch out like a tree, with their main stem or trunk running out the liver through the head of the pancreas (the organ that makes insulin and which contributes its own duct to the main bile duct) to empty into the upper alimentary tract. These ducts, like similar tubular structures in the body, are prey to many diseases that narrow or obstruct them. The diseases may be systemic, like in autoimmune diseases, or local, like cancer of the ducts or the head of the pancreas. Such obstructions or narrowings (known in medical jargon as strictures or stenoses (singular, stenosis)) impair the drainage of bile from the liver, causing bile to spill into the blood stream and urine and turn the eyes, the skin, and the urine shades of yellow. (You probably have heard the word “jaundice”, which means yellowing of the white of the eye). In severe cases the deposition of bile salts in the skin causes generalized intense itching. In addition, the stagnant bile in the dilated ducts, like any stagnant body fluid, can become infected, setting up a serious blood infection that may claim life. Of course, the symptoms and signs of the primary illness contribute to the patient’s medley of symptoms and signs.

For these reasons physicians strive to relieve biliary obstructions when they happen. Such relief, or biliary decompression, may be done by a surgeon, a gastroenterologist, or an interventional radiologist depending on the nature, location, and severity of the obstructing disease. A surgeon will have to open the belly or use a laparoscope to cut out or bypass the disease; a gastroenterologist approaches the problem through the mouth, past the esophagus and the stomach to place a balloon or stent across the obstruction and dilate it; an interventional radiologist enters the ducts through a small skin cut in the side or front of the belly and passes a small tube, called a catheter into the dilated ducts for bile drainage. Sometimes the interventional radiologist’s catheter is insufficient for the patient’s needs due to the nature of the disease, like in advanced bile duct cancer or advanced cancer of the head of the pancreas requiring the interventional radiologist to dilate the narrowing or obstruction and place a stent across it. This is biliary stenting.

How do I prepare for biliary decompression and stenting?
First, you or a designee must ask for and receive from your care provider an account of the merits and demerits of this procedure and its alternatives. When you have done this, you must endorse the procedure by appending your signature on a document called a consent form. It is likely, if you require biliary decompression and stenting, that you are on admission in a hospital which takes the burden of preparation off you. You will need to have nothing by mouth starting the midnight of the day of your procedure to allow safe sedation for the procedure. Your health care provider will screen you for any impairments of your blood’s clotting ability and correct them to avoid serious hemorrhage. You will have to receive some antibiotic to prevent the bacteria that may have colonized the stagnant bile from seeding your blood and causing you serious infection. This is even more paramount and mandatory if you are already sick with blood infection.

How is biliary decompression and stenting done?
You will be brought to the interventional radiology suit on the morning of the procedure and be placed on the procedure table. Following aseptic preparation of the procedure field you will receive intravenous antibiotics and conscious sedation. The skin entry site will be numbed with a local anesthetic and a small skin cut made. Using fluoroscopy or ultrasound for guidance the interventional radiologist will pass a long skinny needle through the skin into the liver and, if subsequent contrast injection into the needle confirms that it is in a dilated duct, the access will be dilated so that a catheter can be advanced across the stricture or obstruction. It is common practice to delay stenting of the obstruction after decompression by several days, because it reduces the chance of seeding the blood stream with bacteria in the stagnant bile. If this staged process is adopted, you will return to the IR suite on another day and the established path used to place a stent across the obstruction. The catheter will then be removed in a few days and after your physician confirms that the stent is letting bile through.

What are the contraindications to biliary decompression and stenting?
Contraindications are conditions that make percutaneous biliary decompression risky. You must let your health care provider know of them before embarking on this procedure. They include:
• Uncorrectable coagulopathy (this means ‘thinning’ of your blood which will make you bleed too much). 
• No safe access to the biliary ducts.

How do I care for a biliary drainage catheter?
It is easy to care for the drainage catheter at home by yourself. You must avoid unintentionally pulling your catheter out; this often happens when people roll around in their sleep, when their caregivers move them around while attending them, or during ambulation when patients step on their drainage bag or tubing while in motion. Your interventional radiologist will see you at specified intervals at the clinic and check your blood electrolytes for any changes that may come from the daily loss of bile. It is good practice to change the catheter every 3 months to keep it from blocking. If, on the other hand, a stent has been placed there is no need for catheter change, but you will be periodically checked for rising bile levels in the blood, because the nature of some of the diseases that cause bile duct obstruction predicts future stent failure.

Peripheral arterial revascularization. Ken. U. Ekechukwu, MD, MPH, FACP.

What is peripheral arterial disease?
An artery carries blood away from the heart, while a vein carries blood to it (except the pulmonary artery which carries blood to the lungs from the heart). Conditions like diabetes mellitus, hypertension, and high cholesterol, especially when controlled poorly, and cigarette smoking damage arteries over time. In time, the damage goes from bulges in arterial walls to complete occlusion that completely obstructs flow.

You may be unaware of these events until an artery loses more than 50% of its lumen, when you begin to cramp in your buttocks, thighs, or legs when you walk and later pain in the legs and feet at rest. Men may develop erectile dysfunction. As time goes on, some people will notice changes in the color of the skin of their legs and feet and some may experience odd sensations, too. Ultimately, if nothing is done, the skin breaks down, wounds refuse to heal or heal slowly, and in extreme cases, gangrene sets in and the patient loses the limb. This spectrum of abnormalities constitutes peripheral arterial disease to distinguish it from a similar condition that occurs in arteries that feed the brain and the heart and can affect, not only the limbs, but also the following vessels:
1. The carotid and vertebral arteries which supply the brain.
2. The renal arteries which supply the kidneys.
3. The mesenteric arteries which supply the bowels and the stomach.

What is peripheral arterial revascularization?
Arterial revascularization is the reopening of occluded arteries or widening of narrowed ones. It is different from surgical arterial bypass in which an artificial conduit or a native vein is connected to normal segments of the artery above and below the diseased segment.  In revascularization a vascular specialist (an interventional radiologist, a vascular surgeon, or a cardiologist) uses various techniques, singly or in combination, to reopen blocked or narrowed native arteries. It may be by balloon angioplasty, cryoplasty, atherectomy, or stenting. When any of these is applied to a peripheral artery the procedure is known as peripheral arterial revascularization.

How is peripheral arterial revascularization performed?
First, you or a designee must ask of and receive from your care provider the merits and demerits of this procedure and its alternatives. When you have done this you must endorse the procedure by signing a document called a consent form. You will take nothing by mouth starting about 12 midnight of the day of your procedure. This allows the safe use of conscious sedation for your procedure. You will be required to take Aspirin and Plavix either before or at the start of the procedure to minimize clot formation in the artery during or shortly after the revascularization. In addition, you will receive large amount of intravenous heparin to complement the effects of Plavix and Aspirin  You will be brought to the interventional radiology suit on the morning of the procedure and be placed on the procedure table and receive conscious sedation. The approach to the diseased vessel depends on what vessel is diseased, but in a majority of people one of the common femoral arteries is punctured. A local anesthetic will be applied at the skin entry site into the artery before puncturing it through a small skin cut. The operator will pass wires, catheters, sheaths, balloons, atherectomy device or a stent into the artery to reopen it. You may stay overnight in the hospital and will take daily Aspirin for life and daily Plavix for 3 to 6 months.

What are the contraindications to peripheral arterial revascularization?
Contraindications are conditions that make a procedure risky. You must ask your healthcare provider what the contraindications of peripheral arterial revascularization are. They include:
• Uncorrectable coagulopathy which is the ‘thinning’ of blood that may make you bleed much.
• Allergy to intravenous contrast agent.
• Poor kidney function which increases the risk of kidney failure after exposure to contrast agent.

Embolization in general. Ken U. Ekechukwu, MD, MPH, FACP.

What is embolization?
The word embolus comes from the Greek word embolus, which means a plug. It is a clot or other plugging material carried by blood from one site to another to obstruct the flow of blood.

Embolization is pathologic when blood clot from a vein in the lower limb or the pelvis is transported to the lungs to stop blood flow and cause acute shortness of breath or death – pulmonary thromboembolism. Pathologic embolization can also occur to any organ in the body, but evokes serious consequences when the organ is the brain, a kidneys, the intestines, the eye, or an extremity.

But embolization can be therapeutic or even life-saving, when a vessel is deliberately obstructed to avoid exsanguination from a hemorrhaging organ. Examples abound: Arteriovenous malformations (AVMs) are embolized to diminish the amount of blood flow through them and avoid heart failure; a vascular tumor destined for removal may be embolized to minimize blood loss during surgery; blood flow into a lacerated or hemorrhaging spleen, liver, pelvic artery or kidney is embolized to avoid shock and death; menstrual abnormalities caused by uterine fibroids are treated by deliberate embolization of the uterine arteries; stubborn nose bleeds, bleeding gut, hemoptysis (coughing up of blood), hemorrhage after child birth can all be embolized to save life.

This discussion is about therapeutic embolization, a practice that came into vogue in 1972 when the use of autologous blood clot (a person’s own blood clot) for embolization was first reported.

How do I prepare for embolization?
Learn about the procedure as much as you can and prepare yourself mentally for it. Most embolizations require hospitalization, conscious sedation (deep sedation with opiates and anxiolytics) and the injection of radiocontrast (dye) into the arteries. For these reasons you should refrain from eating 4 to 6 hours before the procedure. Drink a lot of water on the day before and after the treatment to minimize the adverse effects of the radiocontrast on your kidneys. Report all your medications to your physician before the procedure because there are some you should take and some that you must avoid before your procedure. Diabetics and hypertensives, the elderly, and those with poor kidney function deserve special care by the nature of their conditions and the risks they run in sustaining contrast-induced nephropathy (kidney damage from exposure to dye).

How is embolization done?
The technique of embolization varies with the kind of embolization planned for a patient. Nonetheless, some things are common to all embolizations. For many embolizations, a majority of interventionalists will administer systemic antibiotic to the patient to reduce their risk of infection after the treatment. Then after aseptic preparation of the access site and administration of conscious sedation, access is gained into an artery in your groin or your arm. A catheter is advanced through the access into the artery that feeds the organ or area to be embolized and an angiogram is performed to verify that the tip of the catheter is well-positioned. The embolic agent is injected into the artery under fluoroscopic watch. The choice of the embolization agent is informed by the nature of the disease, the size of the feeding artery, its location, and whether the occlusion of the vessel is temporary or permanent. A final angiogram is obtained to verify that the vessel is occluded and that no other vessel or organ was unintentionally embolized. Following the treatment, you will experience pain in the embolized area but it will be adequately treated with pain medicines. You may be nauseous or actually vomit and unable to hold food down. This is addressed with antiemetics (drugs that blunt or remove the urge to vomit), intravenous fluids, and by avoiding food or drinks until the urge to vomit passes. You may run a low-grade fever that may or may not require treating; it is  a response of your body to embolization. Sometimes there is diminished movement of the bowels, a response to the embolization or, more frequently, a side effect of the medications used to control pain. The use of stool softeners, ambulation, and cutting down on the pain medications usually resolve this problem. The duration of these symptoms, which collectively are called post embolization syndrome, varies from 3 days to 3 weeks.

Who needs embolization?
You will decide with your physician’s guidance whether embolization is what you need for your problem. Embolization may be used to treat the following conditions:
1. To stop rapid or heavy bleeding from an organ injured in trauma.
2. To stop rapid or heavy bleeding from the intestines, the nose, the lungs, the uterus, the urinary bladder, or other organs.
3. To control the growth of and symptoms caused by many tumors of the body.
4. To reduce the amount of blood loss during the surgical removal of certain tumors.
5. To close or isolate abnormal blood vessels from the rest of the circulation like arteriovenous malformations and pseudoaneurysms. This list is not exhaustive and your condition may not be on it.

What are the contraindications to embolization?
1. Unwilling patient: Do not offer embolization to a patient who does not wish to have it. 
2. Coagulopathy: Coagulopathy makes embolization ineffective.
3. Alternative treatment: If there is a better alternative to embolization for a condition, use it.
4. Infection: Treat infection in or around an organ before embolizing it.